Chemotherapy of malaria.
نویسندگان
چکیده
The recent war, which carried troops into al1 the highly malarious regions of the world, gave great impetus to the search for better antimalaria1 drugs. The greatest concerted effort was put forth in the United States under the guidance of the Board for Coordination of Malaria1 Studies. The principal objective was the discovery of a drug of low toxicity which would also be at least one of the following against al1 types of human malaria: a true causal prophylactic, a better therapeutic or suppressive agent than was then available, or a truly curative agent. Under this coordinated program, over 14,000 compounds of various types were screened against severa1 of the avian malarias. The pharmacology and toxicology of many of the compounds of promise were studied in lower mammals, and approximately 100 were finally tested against the human malarias. The principal practica1 results were the development of rational regimens for the use of quinacrine (atabrine), based on its physiological disposition and antimalarial activity; the development of chloroquine, a therapeutic and suppressive agent of great value; and the development of the curative agents pentaquine and isopentaquine. The British effort, although on a smaller scale, resulted in the synthesis and elucidation of the highly interesting drug paludrine. The object of this paper is to set forth the general usefulness of the better chemotherapeutic agents when used for the suppression, alleviation or radical cure of human malaria. Any drug to be generally useful must be effective against Plasmodium falciparum, and it is now known
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ورودعنوان ژورنال:
- Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau
دوره 28 1 شماره
صفحات -
تاریخ انتشار 1949